1cnr

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[[Image:1cnr.jpg|left|200px]]
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{{Seed}}
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[[Image:1cnr.png|left|200px]]
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{{STRUCTURE_1cnr| PDB=1cnr | SCENE= }}
{{STRUCTURE_1cnr| PDB=1cnr | SCENE= }}
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'''CORRELATED DISORDER OF THE PURE PRO22(SLASH)LEU25 FORM OF CRAMBIN AT 150K REFINED TO 1.05 ANGSTROMS RESOLUTION'''
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===CORRELATED DISORDER OF THE PURE PRO22(SLASH)LEU25 FORM OF CRAMBIN AT 150K REFINED TO 1.05 ANGSTROMS RESOLUTION===
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==Overview==
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The high resolution crystal structure of crambin has been based on the crystals containing two sequence forms (the mixed form). Here, we report the crystal structure of the sequence isomer having Pro and Leu at residues 22 and 25 (the PL form). This elimination of the sequence heterogeneity resulted in a simpler structure which permits a more accurate modeling of protein disorder. In the observed disorder, the PL form structure and the mixed form structure have significant differences: 1) the disorder caused by the sequence heterogeneity (Pro2/Ser22, Leu/Ile25, Tyr29) is absent in the PL form; 2) Phe13 and Glu23 disordered in the mixed form have only one conformation in the PL form; and 3) Asn12 has multiple conformations in the PL form. During the study of disorder in the PL form structure, we found that conformational correlation can be inferred from a structure determined with Bragg's reflections by introducing fundamental stereochemical information, van der Waals contact (Gursky, O., Badger, J., Li, Y., and Caspar, D. L. D. (1992) Biophys. J. 63, 1210-1220), although an x-ray structure is an image averaged over a large number of copies and the period of data collection and does not carry direct evidence about correlations. The correlations among Thr2,Arg10, and Ile34 present the clearest example. The dimension of this correlation is comparable with the short-range (4-8 A) correlations in the atomic displacements concluded from the x-ray diffuse scattering experiments (Caspar, D. L. D., Clarage, J. B., Salunke, D. M., and Clarage, M. S. (1988) Nature 322, 659-662; Clarage, J. B., Clarage, M. S., Phillips, W. C., Sweet, R. M., and Caspar, D. L. D. (1992) Proteins 12, 145-157).
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{{ABSTRACT_PUBMED_8188676}}
==About this Structure==
==About this Structure==
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[[Category: Yamano, A.]]
[[Category: Yamano, A.]]
[[Category: Plant seed protein]]
[[Category: Plant seed protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:55:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:59:44 2008''

Revision as of 17:59, 30 June 2008

Image:1cnr.png

Template:STRUCTURE 1cnr

CORRELATED DISORDER OF THE PURE PRO22(SLASH)LEU25 FORM OF CRAMBIN AT 150K REFINED TO 1.05 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8188676

About this Structure

1CNR is a Single protein structure of sequence from Crambe hispanica subsp. abyssinica. Full crystallographic information is available from OCA.

Reference

Correlated disorder of the pure Pro22/Leu25 form of crambin at 150 K refined to 1.05-A resolution., Yamano A, Teeter MM, J Biol Chem. 1994 May 13;269(19):13956-65. PMID:8188676

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