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1cnt

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[[Image:1cnt.gif|left|200px]]
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{{STRUCTURE_1cnt| PDB=1cnt | SCENE= }}
{{STRUCTURE_1cnt| PDB=1cnt | SCENE= }}
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'''CILIARY NEUROTROPHIC FACTOR'''
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===CILIARY NEUROTROPHIC FACTOR===
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==Overview==
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Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating neurodegeneration and nerve injury. The crystal structure of human CNTF has been determined at 2.4 A resolution using multi-wavelength anomalous diffraction (MAD) phasing from a single Yb3+ ions. The structure reveals that CNTF is dimeric, with a novel anti-parallel arrangement of the subunits, not previously observed for other cytokines. Each subunit adopts a double crossover four-helix bundle fold, in which two helices contribute to the dimer interface, whilst two different helices show pronounced kinks. Analysis of the electrostatic surface of CNTF identified residues within these kinked helices that may contact the CNTF receptor-alpha. Solution experiments show that CNTF dimerizes at concentrations &gt; 40 microM. Such dimers are likely to be relevant to the storage of CNTF in the peripheral nerve given the high concentrations present in this tissue. However, it is unlikely that they play a role in engaging the three distinct receptor subunits that comprise the CNTF receptor, given the low concentration of extracellular CNTF and its high potency.
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The line below this paragraph, {{ABSTRACT_PUBMED_7796798}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7796798 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7796798}}
==About this Structure==
==About this Structure==
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[[Category: Growth factor]]
[[Category: Growth factor]]
[[Category: Neurotrophic factor]]
[[Category: Neurotrophic factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:55:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:00:00 2008''

Revision as of 18:00, 30 June 2008

Image:1cnt.png

Template:STRUCTURE 1cnt

CILIARY NEUROTROPHIC FACTOR

Template:ABSTRACT PUBMED 7796798

About this Structure

1CNT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing., McDonald NQ, Panayotatos N, Hendrickson WA, EMBO J. 1995 Jun 15;14(12):2689-99. PMID:7796798

Page seeded by OCA on Mon Jun 30 21:00:00 2008

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