1co1

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[[Image:1co1.gif|left|200px]]
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{{Seed}}
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[[Image:1co1.png|left|200px]]
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{{STRUCTURE_1co1| PDB=1co1 | SCENE= }}
{{STRUCTURE_1co1| PDB=1co1 | SCENE= }}
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'''FOLD OF THE CBFA'''
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===FOLD OF THE CBFA===
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==Overview==
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BACKGROUND: CBFA is the DNA-binding subunit of the transcription factor complex called core binding factor, or CBF. Knockout of the Cbfa2 gene in mice leads to embryonic lethality and a profound block in hematopoietic development. Chromosomal disruptions of the human CBFA gene are associated with a large percentage of human leukemias. RESULTS: Utilizing nuclear magnetic resonance spectroscopy we have determined the three-dimensional fold of the CBFA Runt domain in its DNA-bound state, showing that it is an s-type immunoglobulin (Ig) fold. DNA binding by the Runt domain is shown to be mediated by loop regions located at both ends of the Runt domain Ig fold. A putative site for CBFB binding has been identified; the spatial location of this site provides a rationale for the ability of CBFB to modulate the affinity of the Runt domain for DNA. CONCLUSIONS: Structural comparisons demonstrate that the s-type Ig fold found in the Runt domain is conserved in the Ig folds found in the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, and the T-domain. Thus, these proteins form a family of structurally and functionally related DNA-binding domains. Unlike the other members of this family, the Runt domain utilizes loops at both ends of the Ig fold for DNA recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_10545320}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10545320 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10545320}}
==About this Structure==
==About this Structure==
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1CO1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO1 OCA].
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1CO1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO1 OCA].
==Reference==
==Reference==
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[[Category: Bushweller, J H.]]
[[Category: Bushweller, J H.]]
[[Category: Cbfa runt aml-1 runt domain]]
[[Category: Cbfa runt aml-1 runt domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:56:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:00:24 2008''

Revision as of 18:00, 30 June 2008

Image:1co1.png

Template:STRUCTURE 1co1

FOLD OF THE CBFA

Template:ABSTRACT PUBMED 10545320

About this Structure

1CO1 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains., Berardi MJ, Sun C, Zehr M, Abildgaard F, Peng J, Speck NA, Bushweller JH, Structure. 1999 Oct 15;7(10):1247-56. PMID:10545320

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