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1cq4

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[[Image:1cq4.gif|left|200px]]
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{{Seed}}
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[[Image:1cq4.png|left|200px]]
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{{STRUCTURE_1cq4| PDB=1cq4 | SCENE= }}
{{STRUCTURE_1cq4| PDB=1cq4 | SCENE= }}
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'''CI2 MUTANT WITH TETRAGLUTAMINE (MGQQQQGM) REPLACING MET59'''
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===CI2 MUTANT WITH TETRAGLUTAMINE (MGQQQQGM) REPLACING MET59===
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==Overview==
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We have constructed mutants of chymotrypsin inhibitor 2 with short glutamine repeats inserted into its inhibitory loop. These mutants oligomerize when expressed in Escherichia coli. The dimer of a mutant with four glutamines now has been crystallized, and its structure has been solved by molecular replacement by using the wild-type monomer as a search model. The structure of each half of the dimer is found to be the same as that of the wild-type monomer, except around the glutamine insertion. It was proposed that the components of the oligomers are held together by hydrogen bonds between the main-chain and side-chain amides of the glutamine repeats. Instead, they appear to form by swapping domains on folding in E. coli, and the glutamine repeats connecting the components of the dimers are disordered.
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The line below this paragraph, {{ABSTRACT_PUBMED_9990011}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9990011 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9990011}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Subtilisin- chymotrypsin inhibitor-2]]
[[Category: Subtilisin- chymotrypsin inhibitor-2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:59:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:05:55 2008''

Revision as of 18:05, 30 June 2008

Image:1cq4.png

Template:STRUCTURE 1cq4

CI2 MUTANT WITH TETRAGLUTAMINE (MGQQQQGM) REPLACING MET59

Template:ABSTRACT PUBMED 9990011

About this Structure

1CQ4 is a Protein complex structure of sequences from Hordeum vulgare. Full crystallographic information is available from OCA.

Reference

Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat., Chen YW, Stott K, Perutz MF, Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1257-61. PMID:9990011

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