1cqp

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{{STRUCTURE_1cqp| PDB=1cqp | SCENE= }}
{{STRUCTURE_1cqp| PDB=1cqp | SCENE= }}
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'''CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION'''
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===CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION===
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==Overview==
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The lymphocyte function-associated antigen (LFA-1) belongs to the family of beta2-integrins and plays an important role in T-cell activation and leukocyte migration to sites of inflammation. We report here that lovastatin, a drug clinically used for lowering cholesterol levels, inhibits the interaction of human LFA-1 with its counter-receptor intercellular adhesion molecule-1. Using nuclear magnetic resonance spectroscopy and X-ray crystallography we show that the inhibitor binds to a highly conserved domain of the LFA-1 alpha-chain called the I-domain. The first three-dimensional structure of an integrin inhibitor bound to its receptor reveals atomic details for a hitherto unknown mode of LFA-1 inhibition. It also sheds light into possible mechanisms of LFA-1 mediated signalling and will support the design of novel anti-adhesive and immunosuppressive drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 10493852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10493852}}
==About this Structure==
==About this Structure==
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[[Category: Rossman fold]]
[[Category: Rossman fold]]
[[Category: Structural basis for lfa-1 inhibition]]
[[Category: Structural basis for lfa-1 inhibition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:00:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:09:13 2008''

Revision as of 18:09, 30 June 2008

Image:1cqp.png

Template:STRUCTURE 1cqp

CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION

Template:ABSTRACT PUBMED 10493852

About this Structure

1CQP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain., Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U, J Mol Biol. 1999 Sep 10;292(1):1-9. PMID:10493852

Page seeded by OCA on Mon Jun 30 21:09:13 2008

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