1crw

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{{Seed}}
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{{STRUCTURE_1crw| PDB=1crw | SCENE= }}
{{STRUCTURE_1crw| PDB=1crw | SCENE= }}
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'''CRYSTAL STRUCTURE OF APO-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PALINURUS VERSICOLOR AT 2.0A RESOLUTION'''
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===CRYSTAL STRUCTURE OF APO-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PALINURUS VERSICOLOR AT 2.0A RESOLUTION===
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==Overview==
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d-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) shows cooperative properties for binding coenzymes. The structure of apo-GAPDH from Palinurus versicolor has been solved at 2.0 A resolution by X-ray crystallography. The final model gives a crystallographic R factor of 0.178 in the resolution range 8 to 2 A. The structural comparison with holo-GAPDH from the same species reveals a conformational change induced by coenzyme binding similar to that observed in Bacillus stearothermophilus GAPDH but to a lesser extent. The differences in magnitude during the apo-holo transition between these two enzymes were analyzed with respect to the change of the amino acid composition in the coenzyme binding pocket. In the crystalline state of apo-GAPDH, the overall structures of the subunits are similar to each other; however, significant differences in temperature factors and minor differences in domain rotation upon coenzyme binding were observed for different subunits. These structural features are discussed in relation to the environmental asymmetry of crystallographically independent subunits.
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The line below this paragraph, {{ABSTRACT_PUBMED_10806086}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10806086 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10806086}}
==About this Structure==
==About this Structure==
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[[Category: Song, S.]]
[[Category: Song, S.]]
[[Category: Free-nad gapdh]]
[[Category: Free-nad gapdh]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:03:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:14:36 2008''

Revision as of 18:14, 30 June 2008

Image:1crw.png

Template:STRUCTURE 1crw

CRYSTAL STRUCTURE OF APO-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PALINURUS VERSICOLOR AT 2.0A RESOLUTION

Template:ABSTRACT PUBMED 10806086

About this Structure

1CRW is a Single protein structure of sequence from Palinurus versicolor. Full crystallographic information is available from OCA.

Reference

Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Palinurus versicolor., Shen YQ, Li J, Song SY, Lin ZJ, J Struct Biol. 2000 May;130(1):1-9. PMID:10806086

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