1ctx

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[[Image:1ctx.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ctx| PDB=1ctx | SCENE= }}
{{STRUCTURE_1ctx| PDB=1ctx | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE-LONG-NEUROTOXIN FROM COBRA VENOM'''
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===THREE-DIMENSIONAL STRUCTURE OF THE-LONG-NEUROTOXIN FROM COBRA VENOM===
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==Overview==
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The three-dimensional structure of alpha-cobra-toxin, the "long" neurotoxin from the venom of Naja naja siamensis, has been determined at 2.8-A resolution. Crystals grown as hexagonal needles have space group P6522 with unit cell parameters a = b = 74.59 A, c = 42.89 A; one molecule per asymmetric unit. Phases were determined with a single isomorphous derivative with HgI2 by using the anomalous scattering of the single-site HgI2 molecule to resolve the phase ambiguity. The polypeptide chain folds into three major loops and one tail emerging from a globular head. The protruding long central loop (residues 21-40) is flanked on either side by two shorter loops (residues 4-13 and 44-55); the tail piece (residues 63-71) hangs behind this loop. The molecular conformation is determined by four disulfides in the head and one at the tip of the long loop, by a triple-stranded beta-pleated sheet involving this loop, and by hydrophobic interactions stabilizing the other two loops. The structure of alpha-cobratoxin is compared to that described for the "short" erabutoxin b which shows similar arrangement of structurally and functionally invariant groups.
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The line below this paragraph, {{ABSTRACT_PUBMED_6930640}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 6930640 is the PubMed ID number.
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{{ABSTRACT_PUBMED_6930640}}
==About this Structure==
==About this Structure==
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[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:06:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:21:57 2008''

Revision as of 18:21, 30 June 2008

Image:1ctx.png

Template:STRUCTURE 1ctx

THREE-DIMENSIONAL STRUCTURE OF THE-LONG-NEUROTOXIN FROM COBRA VENOM

Template:ABSTRACT PUBMED 6930640

About this Structure

1CTX is a Single protein structure of sequence from Naja siamensis. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the "long" neurotoxin from cobra venom., Walkinshaw MD, Saenger W, Maelicke A, Proc Natl Acad Sci U S A. 1980 May;77(5):2400-4. PMID:6930640

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