1cun

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[[Image:1cun.gif|left|200px]]
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{{STRUCTURE_1cun| PDB=1cun | SCENE= }}
{{STRUCTURE_1cun| PDB=1cun | SCENE= }}
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'''CRYSTAL STRUCTURE OF REPEATS 16 AND 17 OF CHICKEN BRAIN ALPHA SPECTRIN'''
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===CRYSTAL STRUCTURE OF REPEATS 16 AND 17 OF CHICKEN BRAIN ALPHA SPECTRIN===
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==Overview==
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Spectrin is a vital component of the cytoskeleton, conferring flexibility on cells and providing a scaffold for a variety of proteins. It is composed of tandem, antiparallel coiled-coil repeats. We report four related crystal structures at 1.45 A, 2.0 A, 3.1 A, and 4.0 A resolution of two connected repeats of chicken brain alpha-spectrin. In all of the structures, the linker region between adjacent units is alpha-helical without breaks, kinks, or obvious boundaries. Two features observed in the structures are (1) conformational rearrangement in one repeat, resulting in movement of the position of a loop, and (2) varying degrees of bending at the linker region. These features form the basis of two different models of flexibility: a conformational rearrangement and a bending model. These models provide novel atomic details of spectrin flexibility.
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(as it appears on PubMed at http://www.pubmed.gov), where 10481916 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10481916}}
==About this Structure==
==About this Structure==
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[[Category: Structural protein]]
[[Category: Structural protein]]
[[Category: Two repeats of spectrin]]
[[Category: Two repeats of spectrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:07:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:23:35 2008''

Revision as of 18:23, 30 June 2008

Image:1cun.png

Template:STRUCTURE 1cun

CRYSTAL STRUCTURE OF REPEATS 16 AND 17 OF CHICKEN BRAIN ALPHA SPECTRIN

Template:ABSTRACT PUBMED 10481916

About this Structure

1CUN is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structures of two repeats of spectrin suggest models of flexibility., Grum VL, Li D, MacDonald RI, Mondragon A, Cell. 1999 Aug 20;98(4):523-35. PMID:10481916

Page seeded by OCA on Mon Jun 30 21:23:35 2008

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