1cvo

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{{STRUCTURE_1cvo| PDB=1cvo | SCENE= }}
{{STRUCTURE_1cvo| PDB=1cvo | SCENE= }}
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'''THE SOLUTION STRUCTURE OF CARDIOTOXIN V FROM NAJA NAJA ATRA'''
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===THE SOLUTION STRUCTURE OF CARDIOTOXIN V FROM NAJA NAJA ATRA===
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==Overview==
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Cardiotoxins are small proteins that are found in the venoms of snakes from the Elapidae family. These toxins are known to bind to and disrupt the organization, integrity, and function of the cell membrane. Most of the well-studied cardiotoxins cause depolarization of membrane potentials and/or lysis of red cells. In contrast, CTX V from Naja naja atra displays poor hemolytic activity but is proficient at inducing aggregation and fusion of sphingomyelin vesicles [Chien et al. (1991) J. Biol. Chem. 266, 3252-3259]. To determine whether the unique activity of this CTX is attributable to its tertiary structure, the solution structure of CTX V was determined by NMR methods. On the basis of these studies, this cardiotoxin has the same general topology as other members of the family, and thus its unusual properties do not arise from any gross structural differences that are detectable by solution NMR methods. Molecular dynamics calculations indicate that residues 36-50 show concerted fluctuations. On the basis of sequence similarity, we postulate that residues 30-34 are important in determining the specificity of cardiotoxins for fusion versus lysis of vesicles.
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{{ABSTRACT_PUBMED_8347605}}
==About this Structure==
==About this Structure==
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1CVO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVO OCA].
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1CVO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVO OCA].
==Reference==
==Reference==
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[[Category: Wu, W G.]]
[[Category: Wu, W G.]]
[[Category: Cytotoxin]]
[[Category: Cytotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:30:56 2008''

Revision as of 18:30, 30 June 2008

Image:1cvo.png

Template:STRUCTURE 1cvo

THE SOLUTION STRUCTURE OF CARDIOTOXIN V FROM NAJA NAJA ATRA

Template:ABSTRACT PUBMED 8347605

About this Structure

1CVO is a Single protein structure of sequence from Naja atra. Full experimental information is available from OCA.

Reference

Solution structure of cardiotoxin V from Naja naja atra., Singhal AK, Chien KY, Wu WG, Rule GS, Biochemistry. 1993 Aug 10;32(31):8036-44. PMID:8347605

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