1cvz

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[[Image:1cvz.gif|left|200px]]
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{{STRUCTURE_1cvz| PDB=1cvz | SCENE= }}
{{STRUCTURE_1cvz| PDB=1cvz | SCENE= }}
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'''CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)'''
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===CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)===
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==Overview==
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Papain was used as an experimental model structure to understand the inhibition mechanism of newly developed specific inhibitors of cathepsin L, the papain superfamily. Recently, we developed a series of cathepsin L-specific inhibitors which are called the CLIK series [(1999) FEBS Lett. 458, 6-10]. Here, we report the complex structure of papain with CLIK148, which is a representative inhibitor from the CLIK series. The inhibitor complex structure was solved at 1.7 A resolution with conventional R 0.177. Unlike other epoxisuccinate inhibitors (E64, CA030, and CA074), CLIK148 uses both prime and nonprime sites, which are important for the specific inhibitory effect on cathepsin L. Also, the specificity for cathepsin L could be explained by the existence of Phe in the P2 site and hydrophobic interaction of N-terminal pyridine ring.
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(as it appears on PubMed at http://www.pubmed.gov), where 10600517 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10600517}}
==About this Structure==
==About this Structure==
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[[Category: Papain]]
[[Category: Papain]]
[[Category: Sulfhydryl proteinase]]
[[Category: Sulfhydryl proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:10:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:33:47 2008''

Revision as of 18:33, 30 June 2008

Image:1cvz.png

Template:STRUCTURE 1cvz

CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)

Template:ABSTRACT PUBMED 10600517

About this Structure

1CVZ is a Single protein structure of sequence from Carica papaya. Full crystallographic information is available from OCA.

Reference

Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex., Tsuge H, Nishimura T, Tada Y, Asao T, Turk D, Turk V, Katunuma N, Biochem Biophys Res Commun. 1999 Dec 20;266(2):411-6. PMID:10600517

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