1cwo

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{{STRUCTURE_1cwo| PDB=1cwo | SCENE= }}
{{STRUCTURE_1cwo| PDB=1cwo | SCENE= }}
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'''HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN'''
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===HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN===
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==Overview==
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The crystal structure of (Thr2, Leu5, d-Hiv8, Leu10)-cyclosporin (cyclic peptolide SDZ 214-103) has been determined as the unbound crystal form and as a complex with human cyclophilin A. This pair of structures provides an example of a significant difference in conformation between free and bound ligand in crystals. The conformation of the unbound form is unlike that of both free and bound conformations of cyclosporin A (with the amide bond between residues 3 and 4 in the cis conformation), while the bound conformation is similar to that of CsA bound to cyclophilin. The cyclophilin-bound conformations of both ligands are similar, though this involves a significantly different waterellipsisligand hydrogen-bonding structure, which compensates for the chemical differences between the two ligands.
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The line below this paragraph, {{ABSTRACT_PUBMED_9769217}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9769217 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9769217}}
==About this Structure==
==About this Structure==
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[[Category: Taylor, P.]]
[[Category: Taylor, P.]]
[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:11:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:38:36 2008''

Revision as of 18:38, 30 June 2008

Image:1cwo.png

Template:STRUCTURE 1cwo

HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN

Template:ABSTRACT PUBMED 9769217

About this Structure

1CWO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A., Mikol V, Taylor P, Kallen J, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):451-61. PMID:9769217

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