1cww

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[[Image:1cww.gif|left|200px]]
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{{STRUCTURE_1cww| PDB=1cww | SCENE= }}
{{STRUCTURE_1cww| PDB=1cww | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1'''
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===SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1===
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==Overview==
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Activation of procaspase-9, a key component of the apoptosis mechanism, requires the interaction of its caspase recruitment domain (CARD) with the CARD in the adaptor protein Apaf-1. Using nuclear magnetic resonance spectroscopy and mutagenesis we have determined the structure of the CARD from Apaf-1 and the residues important for binding the CARD in procaspase-9. Apaf-1's CARD contains seven short alpha-helices with the core six helices arranged in an antiparallel manner. Residues in helix 2 have a central role in mediating interaction with procaspase-9 CARD. This interaction surface is distinct from that proposed based on the structure of the CARD from RAIDD, but is coincident with that of the structurally similar FADD death effector domain and the Apaf-1 CARD interface identified by crystallographic studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 10578182 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10578182}}
==About this Structure==
==About this Structure==
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1CWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWW OCA].
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1CWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWW OCA].
==Reference==
==Reference==
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[[Category: Vaux, D L.]]
[[Category: Vaux, D L.]]
[[Category: Helical bundle]]
[[Category: Helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:12:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:39:59 2008''

Revision as of 18:40, 30 June 2008

Image:1cww.png

Template:STRUCTURE 1cww

SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1

Template:ABSTRACT PUBMED 10578182

About this Structure

1CWW is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1., Day CL, Dupont C, Lackmann M, Vaux DL, Hinds MG, Cell Death Differ. 1999 Nov;6(11):1125-32. PMID:10578182

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