1cwv

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{{STRUCTURE_1cwv| PDB=1cwv | SCENE= }}
{{STRUCTURE_1cwv| PDB=1cwv | SCENE= }}
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'''CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN'''
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===CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN===
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==Overview==
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The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2.3 angstrom crystal structure of the invasin extracellular region reveals five domains that form a 180 angstrom rod with structural similarities to tandem fibronectin type III domains. The integrin-binding surfaces of invasin and fibronectin include similarly located key residues, but in the context of different folds and surface shapes. The structures of invasin and fibronectin provide an example of convergent evolution, in which invasin presents an optimized surface for integrin binding, in comparison with host substrates.
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(as it appears on PubMed at http://www.pubmed.gov), where 10514372 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10514372}}
==About this Structure==
==About this Structure==
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[[Category: Integrin-binding protein]]
[[Category: Integrin-binding protein]]
[[Category: Inv gene]]
[[Category: Inv gene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:12:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:40:12 2008''

Revision as of 18:40, 30 June 2008

Image:1cwv.png

Template:STRUCTURE 1cwv

CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN

Template:ABSTRACT PUBMED 10514372

About this Structure

1CWV is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of invasin: a bacterial integrin-binding protein., Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ, Science. 1999 Oct 8;286(5438):291-5. PMID:10514372

Page seeded by OCA on Mon Jun 30 21:40:12 2008

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