1cxv

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[[Image:1cxv.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1cxv| PDB=1cxv | SCENE= }}
{{STRUCTURE_1cxv| PDB=1cxv | SCENE= }}
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'''STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)'''
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===STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)===
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==Overview==
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The matrix metalloproteinases are crucial in the physiological and pathological degradation of the mammalian extracellular matrix, including breast tumours, and osteoarthritic cartilage. These enzymes are classified according to their matrix substrate specificity. Collagenase-3 (MMP-13) is a member of this family and preferentially cleaves type II collagen, cartilage, fibronectin and aggrecan. Collagenase-3 is normally expressed in hypertrophic chondrocytes, periosteal cells, and osteoblasts during bone development. The structure of the catalytic domain of recombinant mouse collagenase-3, complexed to the hydroxamate inhibitor (RS-113456), is reported at 2.0 A resolution. Molecular replacement and weak phasing information from a single derivative determined the structure. Neither molecular replacement nor derivative methods had a sufficient radius of convergence to yield a refinable structure. The structure illuminates the atomic zinc ion interactions with functional groups in the active site, emphasizing zinc ligation and the very voluminous hydrophobic P1' group for the inhibitor potency. The structure provides insight into the specificity of this enzyme, facilitating design of specific inhibitors to target various diseases.
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The line below this paragraph, {{ABSTRACT_PUBMED_10525409}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10525409 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10525409}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:13:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:44:21 2008''

Revision as of 18:44, 30 June 2008

Image:1cxv.png

Template:STRUCTURE 1cxv

STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)

Template:ABSTRACT PUBMED 10525409

About this Structure

1CXV is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of recombinant mouse collagenase-3 (MMP-13)., Botos I, Meyer E, Swanson SM, Lemaitre V, Eeckhout Y, Meyer EF, J Mol Biol. 1999 Oct 1;292(4):837-44. PMID:10525409

Page seeded by OCA on Mon Jun 30 21:44:21 2008

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