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1cy5

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[[Image:1cy5.gif|left|200px]]
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{{STRUCTURE_1cy5| PDB=1cy5 | SCENE= }}
{{STRUCTURE_1cy5| PDB=1cy5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE APAF-1 CARD'''
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===CRYSTAL STRUCTURE OF THE APAF-1 CARD===
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==Overview==
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The caspase recruitment domain (CARD) of Apaf-1 binds to the CARD of caspase-9 to trigger a proteolytic cascade that leads to apoptotic cell death. We report the crystal structure of the Apaf-1 CARD at 1. 3 A resolution, solved in a two-element multiwavelength anomalous dispersion (MAD) X-ray diffraction experiment. This CARD adopts a six-helix bundle fold with Greek key topology surrounding an extensive hydrophobic core. This fold, which we call the "death fold", is found in other domains that mediate interactions in apoptotic signaling despite very low sequence identity. From a structure-based alignment, we identify conserved patterns that characterize the death fold and its subclasses. Like the Ig-fold, it provides a rigid structural scaffold upon which diverse recognition surfaces are assembled.
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(as it appears on PubMed at http://www.pubmed.gov), where 10543941 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10543941}}
==About this Structure==
==About this Structure==
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[[Category: Greek key topology]]
[[Category: Greek key topology]]
[[Category: Six alpha-helix bundle]]
[[Category: Six alpha-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:14:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:45:54 2008''

Revision as of 18:45, 30 June 2008

Image:1cy5.png

Template:STRUCTURE 1cy5

CRYSTAL STRUCTURE OF THE APAF-1 CARD

Template:ABSTRACT PUBMED 10543941

About this Structure

1CY5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling., Vaughn DE, Rodriguez J, Lazebnik Y, Joshua-Tor L, J Mol Biol. 1999 Oct 29;293(3):439-47. PMID:10543941

Page seeded by OCA on Mon Jun 30 21:45:54 2008

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