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1d0a

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[[Image:1d0a.gif|left|200px]]
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{{Seed}}
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[[Image:1d0a.png|left|200px]]
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{{STRUCTURE_1d0a| PDB=1d0a | SCENE= }}
{{STRUCTURE_1d0a| PDB=1d0a | SCENE= }}
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'''STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE'''
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===STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE===
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==Overview==
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Many members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting TNFR-associated factors (TRAFs) through their cytoplasmic tails. TRAFs apparently recognize highly diverse receptor sequences. Crystal structures of the TRAF domain of human TRAF2 in complex with peptides from the TNFR family members CD40, CD30, Ox40, 4-1BB, and the EBV oncoprotein LMP1 revealed a conserved binding mode. A major TRAF2-binding consensus sequence, (P/S/A/T)x(Q/E)E, and a minor consensus motif, PxQxxD, can be defined from the structural analysis, which encompass all known TRAF2-binding sequences. The structural information provides a template for the further dissection of receptor binding specificity of TRAF2 and for the understanding of the complexity of TRAF-mediated signal transduction.
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The line below this paragraph, {{ABSTRACT_PUBMED_10518213}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10518213 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10518213}}
==About this Structure==
==About this Structure==
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[[Category: B-sandwich]]
[[Category: B-sandwich]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:18:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:55:48 2008''

Revision as of 18:55, 30 June 2008

Image:1d0a.png

Template:STRUCTURE 1d0a

STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE

Template:ABSTRACT PUBMED 10518213

About this Structure

1D0A is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for the recognition of diverse receptor sequences by TRAF2., Ye H, Park YC, Kreishman M, Kieff E, Wu H, Mol Cell. 1999 Sep;4(3):321-30. PMID:10518213

Page seeded by OCA on Mon Jun 30 21:55:48 2008

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