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1gp6

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(New page: 200px<br /> <applet load="1gp6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gp6, resolution 1.75&Aring;" /> '''ANTHOCYANIDIN SYNTH...)
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Revision as of 17:39, 29 October 2007

Image:1gp6.gif

1gp6, resolution 1.75Å

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ANTHOCYANIDIN SYNTHASE FROM ARABIDOPSIS THALIANA COMPLEXED WITH TRANS-DIHYDROQUERCETIN (WITH 30 MIN EXPOSURE TO O2)

Overview

Flavonoids are common colorants in plants and have long-established, biomedicinal properties. Anthocyanidin synthase (ANS), a 2-oxoglutarate, iron-dependent oxygenase, catalyzes the penultimate step in the, biosynthesis of the anthocyanin class of flavonoids. The crystal structure, of ANS reveals a multicomponent active site containing metal, cosubstrate, and two molecules of a substrate analog (dihydroquercetin). An additional, structure obtained after 30 min exposure to dioxygen is consistent with, the oxidation of the dihydroquercetin to quercetin and the concomitant, decarboxylation of 2-oxoglutarate to succinate. Together with in vitro, studies, the crystal structures suggest a mechanism for ANS-catalyzed, anthocyanidin formation from the natural leucoanthocyanidin substrates, ... [(full description)]

About this Structure

1GP6 is a [Single protein] structure of sequence from [Arabidopsis thaliana] with FE2, SIN, MES, QUE and DH2 as [ligands]. Full crystallographic information is available from [OCA].

Reference

Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana., Wilmouth RC, Turnbull JJ, Welford RW, Clifton IJ, Prescott AG, Schofield CJ, Structure. 2002 Jan;10(1):93-103. PMID:11796114

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