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1d1h

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[[Image:1d1h.gif|left|200px]]
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{{STRUCTURE_1d1h| PDB=1d1h | SCENE= }}
{{STRUCTURE_1d1h| PDB=1d1h | SCENE= }}
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'''SOLUTION STRUCTURE OF HANATOXIN 1'''
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===SOLUTION STRUCTURE OF HANATOXIN 1===
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==Overview==
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The three-dimensional structure of hanatoxin1 (HaTx1) was determined by using NMR spectroscopy. HaTx1 is a 35 amino acid residue peptide toxin that inhibits the drk1 voltage-gated K(+) channel not by blocking the pore, but by altering the energetics of gating. Both the amino acid sequence of HaTx1 and its unique mechanism of action distinguish this toxin from the previously described K(+) channel inhibitors. Unlike most other K(+) channel-blocking toxins, HaTx1 adopts an "inhibitor cystine knot" motif and is composed of two beta-strands, strand I for residues 19-21 and strand II for residues 28-30, connected by four chain reversals. A comparison of the surface features of HaTx1 with those of other gating modifier toxins of voltage-gated Ca(2+) and Na(+) channels suggests that the combination of a hydrophobic patch and surrounding charged residues is principally responsible for the binding of gating modifier toxins to voltage-gated ion channels.
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(as it appears on PubMed at http://www.pubmed.gov), where 10731427 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10731427}}
==About this Structure==
==About this Structure==
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1D1H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Grammostola_rosea Grammostola rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1H OCA].
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1D1H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Grammostola_rosea Grammostola rosea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1H OCA].
==Reference==
==Reference==
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[[Category: Takahashi, H.]]
[[Category: Takahashi, H.]]
[[Category: Cystine knot]]
[[Category: Cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:20:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:04:34 2008''

Revision as of 19:04, 30 June 2008

Image:1d1h.png

Template:STRUCTURE 1d1h

SOLUTION STRUCTURE OF HANATOXIN 1

Template:ABSTRACT PUBMED 10731427

About this Structure

1D1H is a Single protein structure of sequence from Grammostola rosea. Full experimental information is available from OCA.

Reference

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins., Takahashi H, Kim JI, Min HJ, Sato K, Swartz KJ, Shimada I, J Mol Biol. 2000 Mar 31;297(3):771-80. PMID:10731427

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