1d27

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{{STRUCTURE_1d27| PDB=1d27 | SCENE= }}
{{STRUCTURE_1d27| PDB=1d27 | SCENE= }}
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'''HIGH-RESOLUTION STRUCTURE OF A MUTAGENIC LESION IN DNA'''
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===HIGH-RESOLUTION STRUCTURE OF A MUTAGENIC LESION IN DNA===
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==Overview==
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The self-complementary dodecanucleotide d[CGC(m6G)AATTTGCG]2 (where m6G is O6-methylguanine), which contains two m6G.T base pairs, has been analyzed by x-ray diffraction methods and the structure has been refined to a residual error of R = 0.185 at 2.0-A resolution. The m6G.T mispair closely resembles a Watson-Crick base pair and there are very few structural differences between the m6G.T duplex and the native analogue. The similarity between the m6G.T base pair and a normal G.C base pair explains the failure of mismatch repair enzymes to recognize and remove this mutagenic lesion. A series of ultraviolet melting studies over a wide pH range on a related dodecamer indicate that the m6G.C mispair can exist in two conformations; one is a wobble pair and the other is a protonated Watson-Crick pair. The former, which predominates at physiological pH, will be removed by normal proofreading and repair enzymes, whereas the latter is likely to escape detection. Hence, the occasional occurrence of the protonated m6G.C base pair may explain why the presence of m6G in genomic DNA does not always give rise to a mutation.
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The line below this paragraph, {{ABSTRACT_PUBMED_2263612}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2263612 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2263612}}
==About this Structure==
==About this Structure==
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[[Category: Mismatched]]
[[Category: Mismatched]]
[[Category: Modified]]
[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:21:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:11:07 2008''

Revision as of 19:11, 30 June 2008

Image:1d27.png

Template:STRUCTURE 1d27

HIGH-RESOLUTION STRUCTURE OF A MUTAGENIC LESION IN DNA

Template:ABSTRACT PUBMED 2263612

About this Structure

Full crystallographic information is available from OCA.

Reference

High-resolution structure of a mutagenic lesion in DNA., Leonard GA, Thomson J, Watson WP, Brown T, Proc Natl Acad Sci U S A. 1990 Dec;87(24):9573-6. PMID:2263612

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