1d2e

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{{Seed}}
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{{STRUCTURE_1d2e| PDB=1d2e | SCENE= }}
{{STRUCTURE_1d2e| PDB=1d2e | SCENE= }}
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'''CRYSTAL STRUCTURE OF MITOCHONDRIAL EF-TU IN COMPLEX WITH GDP'''
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===CRYSTAL STRUCTURE OF MITOCHONDRIAL EF-TU IN COMPLEX WITH GDP===
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==Overview==
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The crystal structure of bovine mitochondrial elongation factor Tu (EF-Tu) in complex with GDP has been determined at a resolution of 1. 94 A. The structure is similar to that of EF-Tu:GDP from Escherichia coli and Thermus aquaticus, but the orientation of the GDP-binding domain 1 is changed relative to domains 2 and 3. Sixteen conserved water molecules common to EF-Tu and other G-proteins in the GDP-binding site are described. These water molecules create a network linking separated parts of the binding pocket. Mitochondrial EF-Tu binds nucleotides less tightly than prokaryotic EF-Tu possibly due to an increased mobility in regions close to the GDP-binding site. The C-terminal extension of mitochondrial EF-Tu has structural similarities with DNA recognising zinc fingers suggesting that the extension may be involved in recognition of RNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 10715211 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10715211}}
==About this Structure==
==About this Structure==
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[[Category: Beta-barrel]]
[[Category: Beta-barrel]]
[[Category: G-protein]]
[[Category: G-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:22:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:11:30 2008''

Revision as of 19:11, 30 June 2008

Image:1d2e.png

Template:STRUCTURE 1d2e

CRYSTAL STRUCTURE OF MITOCHONDRIAL EF-TU IN COMPLEX WITH GDP

Template:ABSTRACT PUBMED 10715211

About this Structure

1D2E is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP., Andersen GR, Thirup S, Spremulli LL, Nyborg J, J Mol Biol. 2000 Mar 24;297(2):421-36. PMID:10715211

Page seeded by OCA on Mon Jun 30 22:11:30 2008

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