1d4b

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{{STRUCTURE_1d4b| PDB=1d4b | SCENE= }}
{{STRUCTURE_1d4b| PDB=1d4b | SCENE= }}
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'''CIDE-N DOMAIN OF HUMAN CIDE-B'''
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===CIDE-N DOMAIN OF HUMAN CIDE-B===
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==Overview==
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Apoptotic DNA fragmentation and chromatin condensation are mediated by the caspase-activated DFF40/ CAD nuclease, which is chaperoned and inhibited by DFF45/ICAD. CIDE proteins share a homologous regulatory CIDE-N domain with DFF40/CAD and DFF45/ ICAD. Here we report the solution structure of CIDE-N of human CIDE-B. We show that the CIDE-N of CIDE-B interacts with CIDE-N domains of both DFF40 and DFF45. The binding epitopes are similar and map to a highly charged bipolar surface region of CIDE-B. Furthermore, we demonstrate that the CIDE-N of CIDE-B regulates enzymatic activity of the DFF40/ DFF45 complex in vitro. Based on these results and mutagenesis data, we propose a model for the CIDE-N/ CIDE-N complex and discuss the role of this novel bipolar interaction in mediating downstream events of apoptosis.
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{{ABSTRACT_PUBMED_10619428}}
==About this Structure==
==About this Structure==
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1D4B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4B OCA].
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1D4B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4B OCA].
==Reference==
==Reference==
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[[Category: Zhou, P.]]
[[Category: Zhou, P.]]
[[Category: Alpha/beta roll]]
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Revision as of 19:23, 30 June 2008

Image:1d4b.png

Template:STRUCTURE 1d4b

CIDE-N DOMAIN OF HUMAN CIDE-B

Template:ABSTRACT PUBMED 10619428

About this Structure

1D4B is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis., Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G, Cell. 1999 Dec 23;99(7):747-55. PMID:10619428

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