1d5g

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[[Image:1d5g.gif|left|200px]]
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{{STRUCTURE_1d5g| PDB=1d5g | SCENE= }}
{{STRUCTURE_1d5g| PDB=1d5g | SCENE= }}
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'''SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E COMPLEXED WITH A PEPTIDE'''
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===SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E COMPLEXED WITH A PEPTIDE===
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==Overview==
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The solution structure of the second PDZ domain from human phosphatase hPTP1E in complex with a C-terminal peptide from the guanine nucleotide exchange factor RA-GEF-2 has been determined using 2D and 3D heteronuclear NMR experiments. Compared to previously solved structures, the hPTP1E complex shows an enlarged interaction surface with the C terminus of the bound peptide. Novel contacts were found between the long structured beta2/beta3 loop of the PDZ domain and the sixth amino acid residue from the C terminus of the peptide. This work underlines the importance of the beta2/beta3 loop for ligand selection by PDZ domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 12095257 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12095257}}
==About this Structure==
==About this Structure==
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1D5G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5G OCA].
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1D5G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5G OCA].
==Reference==
==Reference==
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[[Category: Kozlov, G.]]
[[Category: Kozlov, G.]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:28:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:27:07 2008''

Revision as of 19:27, 30 June 2008

Image:1d5g.png

Template:STRUCTURE 1d5g

SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E COMPLEXED WITH A PEPTIDE

Template:ABSTRACT PUBMED 12095257

About this Structure

1D5G is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions., Kozlov G, Banville D, Gehring K, Ekiel I, J Mol Biol. 2002 Jul 19;320(4):813-20. PMID:12095257

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