1d64

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{{Seed}}
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{{STRUCTURE_1d64| PDB=1d64 | SCENE= }}
{{STRUCTURE_1d64| PDB=1d64 | SCENE= }}
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'''CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES'''
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===CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES===
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==Overview==
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The crystal structure of the complex formed between the dodecanucleotide d(CGCGAATTCGCG)2 and the drug pentamidine, which is active against the Pneumocystis carinii pathogen in AIDS patients, has been determined to a resolution of 2.1 A and an R-factor of 19.4%. Analysis of the structure has shown the drug to be bound in the 5'-AATT minor groove region of the duplex, with the amidinium groups H-bonded to adenine N3 atoms in an interstrand manner. The drug molecule adopts an extended conformation, and the immediate binding site spans four base pairs. Structural details of the drug-DNA interactions are discussed, and comparison is made with the dodecamer complex of the structurally similar berenil ligand.
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The line below this paragraph, {{ABSTRACT_PUBMED_1643044}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1643044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1643044}}
==About this Structure==
==About this Structure==
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[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:29:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:30:59 2008''

Revision as of 19:31, 30 June 2008

Image:1d64.png

Template:STRUCTURE 1d64

CRYSTAL STRUCTURE OF A PENTAMIDINE-OLIGONUCLEOTIDE COMPLEX: IMPLICATIONS FOR DNA-BINDING PROPERTIES

Template:ABSTRACT PUBMED 1643044

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties., Edwards KJ, Jenkins TC, Neidle S, Biochemistry. 1992 Aug 11;31(31):7104-9. PMID:1643044

Page seeded by OCA on Mon Jun 30 22:30:59 2008

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