1d7m

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{{STRUCTURE_1d7m| PDB=1d7m | SCENE= }}
{{STRUCTURE_1d7m| PDB=1d7m | SCENE= }}
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'''COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I'''
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===COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I===
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==Overview==
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BACKGROUND: The parallel two-stranded alpha-helical coiled coil is the most frequently encountered subunit-oligomerization motif in proteins. The simplicity and regularity of this motif have made it an attractive system to explore some of the fundamental principles of protein folding and stability and to test the principles of de novo design. RESULTS: The X-ray crystal structure of the 18-heptad-repeat alpha-helical coiled-coil domain of the actin-bundling protein cortexillin I from Dictyostelium discoideum is a tightly packed parallel two-stranded alpha-helical coiled coil. It harbors a distinct 14-residue sequence motif that is essential for coiled-coil formation, and is a prerequisite for the assembly of cortexillin I. The atomic structure reveals novel types of ionic coiled-coil interactions. In particular, the structure shows that a characteristic interhelical and intrahelical salt-bridge pattern, in combination with the hydrophobic interactions occurring at the dimer interface, is the key structural feature of its coiled-coil trigger site. CONCLUSIONS: The knowledge gained from the structure could be used in the de novo design of alpha-helical coiled coils for applications such as two-stage drug targeting and delivery systems, and in the design of coiled coils as templates for combinatorial helical libraries in drug discovery and as synthetic carrier molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 10745004 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10745004}}
==About this Structure==
==About this Structure==
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[[Category: Coiled-coil trigger site]]
[[Category: Coiled-coil trigger site]]
[[Category: Dimerization]]
[[Category: Dimerization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:37:55 2008''

Revision as of 19:37, 30 June 2008

Image:1d7m.png

Template:STRUCTURE 1d7m

COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I

Template:ABSTRACT PUBMED 10745004

About this Structure

1D7M is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges., Burkhard P, Kammerer RA, Steinmetz MO, Bourenkov GP, Aebi U, Structure. 2000 Mar 15;8(3):223-30. PMID:10745004

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