1d7o

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{{Seed}}
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{{STRUCTURE_1d7o| PDB=1d7o | SCENE= }}
{{STRUCTURE_1d7o| PDB=1d7o | SCENE= }}
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'''CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN'''
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===CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN===
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==Overview==
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Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of E. coli and Brassica napus ENR with triclosan and NAD(+) which reveal how triclosan acts as a site-directed, picomolar inhibitor of the enzyme by mimicking its natural substrate. Elements of both the protein and the nucleotide cofactor play important roles in triclosan recognition, providing an explanation for the factors controlling its tight binding to the enzyme and for the emergence of triclosan resistance.
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(as it appears on PubMed at http://www.pubmed.gov), where 10610777 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10610777}}
==About this Structure==
==About this Structure==
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[[Category: Enoyl reductase]]
[[Category: Enoyl reductase]]
[[Category: Triclosan]]
[[Category: Triclosan]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:38:05 2008''

Revision as of 19:38, 30 June 2008

Image:1d7o.png

Template:STRUCTURE 1d7o

CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN

Template:ABSTRACT PUBMED 10610777

About this Structure

1D7O is a Single protein structure of sequence from Brassica napus. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of triclosan bound to enoyl reductase., Roujeinikova A, Levy CW, Rowsell S, Sedelnikova S, Baker PJ, Minshull CA, Mistry A, Colls JG, Camble R, Stuitje AR, Slabas AR, Rafferty JB, Pauptit RA, Viner R, Rice DW, J Mol Biol. 1999 Nov 26;294(2):527-35. PMID:10610777

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