1d7q

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[[Image:1d7q.jpg|left|200px]]
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{{Seed}}
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[[Image:1d7q.png|left|200px]]
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{{STRUCTURE_1d7q| PDB=1d7q | SCENE= }}
{{STRUCTURE_1d7q| PDB=1d7q | SCENE= }}
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'''HUMAN TRANSLATION INITIATION FACTOR EIF1A'''
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===HUMAN TRANSLATION INITIATION FACTOR EIF1A===
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==Overview==
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The translation initiation factor eIF1A is necessary for directing the 43S preinitiation complex from the 5' end of the mRNA to the initiation codon in a process termed scanning. We have determined the solution structure of human eIF1A, which reveals an oligonucleotide-binding (OB) fold and an additional domain. NMR titration experiments showed that eIF1A binds single-stranded RNA oligonucleotides in a site-specific, but non-sequence-specific manner, hinting at an mRNA interaction rather than specific rRNA or tRNA binding. The RNA binding surface extends over a large area covering the canonical OB fold binding site as well as a groove leading to the second domain. Site-directed mutations at multiple positions along the RNA-binding surface were defective in the ability to properly assemble preinitiation complexes at the AUG codon in vitro.
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(as it appears on PubMed at http://www.pubmed.gov), where 10678173 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10678173}}
==About this Structure==
==About this Structure==
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1D7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7Q OCA].
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1D7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7Q OCA].
==Reference==
==Reference==
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[[Category: Ob-fold]]
[[Category: Ob-fold]]
[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:32:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:38:21 2008''

Revision as of 19:38, 30 June 2008

Image:1d7q.png

Template:STRUCTURE 1d7q

HUMAN TRANSLATION INITIATION FACTOR EIF1A

Template:ABSTRACT PUBMED 10678173

About this Structure

1D7Q is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The eIF1A solution structure reveals a large RNA-binding surface important for scanning function., Battiste JL, Pestova TV, Hellen CU, Wagner G, Mol Cell. 2000 Jan;5(1):109-19. PMID:10678173

Page seeded by OCA on Mon Jun 30 22:38:21 2008

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