This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1db5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1db5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1db5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1db5| PDB=1db5 | SCENE= }}
{{STRUCTURE_1db5| PDB=1db5 | SCENE= }}
-
'''HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6'''
+
===HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6===
-
==Overview==
+
<!--
-
A lead compound obtained from a high volume human non-pancreatic secretory phospholipase A2 (hnps-PLA2) screen has been developed into a potent inhibitor using detailed structural knowledge of inhibitor binding to the enzyme active site. Four crystal structures of hnps-PLA2 complexed with a series of increasingly potent indole inhibitors were determined and used as the structural basis for both understanding this binding and providing valuable insights for further development. The application of structure-based drug design has made possible improvements in the binding of this screening lead to the enzyme by nearly three orders of magnitude. Furthermore, the optimized structure (LY311727) displayed 1,500-fold selectivity when assayed against porcine pancreatic s-PLA2.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7664108}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7664108 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7664108}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: S-pla2]]
[[Category: S-pla2]]
[[Category: Structure-based drug design]]
[[Category: Structure-based drug design]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:39:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:46:18 2008''

Revision as of 19:46, 30 June 2008

Image:1db5.png

Template:STRUCTURE 1db5

HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6

Template:ABSTRACT PUBMED 7664108

About this Structure

1DB5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2., Schevitz RW, Bach NJ, Carlson DG, Chirgadze NY, Clawson DK, Dillard RD, Draheim SE, Hartley LW, Jones ND, Mihelich ED, et al., Nat Struct Biol. 1995 Jun;2(6):458-65. PMID:7664108

Page seeded by OCA on Mon Jun 30 22:46:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1db5"
Personal tools