1dbh

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{{STRUCTURE_1dbh| PDB=1dbh | SCENE= }}
{{STRUCTURE_1dbh| PDB=1dbh | SCENE= }}
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'''DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1'''
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===DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1===
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==Overview==
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Proteins containing Dbl homology (DH) domains activate Rho-family GTPases by functioning as specific guanine nucleotide exchange factors. All known DH domains have associated C-terminal pleckstrin homology (PH) domains that are implicated in targeting and regulatory functions. The crystal structure of a fragment of the human Son of sevenless protein containing the DH and PH domains has been determined at 2.3 A resolution. The entirely alpha-helical DH domain is unrelated in architecture to other nucleotide exchange factors. The active site of the DH domain, identified on the basis of sequence conservation and structural features, lies near the interface between the DH and PH domains. The structure suggests that ligation of the PH domain will be coupled structurally to the GTPase binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 9790532 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9790532}}
==About this Structure==
==About this Structure==
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[[Category: Soisson, S M.]]
[[Category: Soisson, S M.]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Guanine nucleotide exchange factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:46:44 2008''

Revision as of 19:46, 30 June 2008

Image:1dbh.png

Template:STRUCTURE 1dbh

DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1

Template:ABSTRACT PUBMED 9790532

About this Structure

1DBH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein., Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J, Cell. 1998 Oct 16;95(2):259-68. PMID:9790532

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