1dbq

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[[Image:1dbq.jpg|left|200px]]
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{{STRUCTURE_1dbq| PDB=1dbq | SCENE= }}
{{STRUCTURE_1dbq| PDB=1dbq | SCENE= }}
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'''DNA-BINDING REGULATORY PROTEIN'''
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===DNA-BINDING REGULATORY PROTEIN===
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==Overview==
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The modulation of the affinity of DNA-binding proteins by small molecule effectors for cognate DNA sites is common to both prokaryotes and eukaryotes. However, the mechanisms by which effector binding to one domain affects DNA binding by a distal domain are poorly understood structurally. In initial studies to provide insight into the mechanism of effector-modulated DNA binding of the lactose repressor family, we determined the crystal structure of the purine repressor bound to a corepressor and purF operator. To extend our understanding, we have determined the structure of the corepressor-free corepressor-binding domain of the purine repressor at 2.2 A resolution. In the unliganded state, structural changes in the corepressor-binding pocket cause each subunit to rotate open by as much as 23 degrees, the consequences of which are the disengagement of the minor groove-binding hinge helices and repressor-DNA dissociation.
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(as it appears on PubMed at http://www.pubmed.gov), where 7553867 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7553867}}
==About this Structure==
==About this Structure==
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[[Category: Purine repressor]]
[[Category: Purine repressor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:39:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:47:17 2008''

Revision as of 19:47, 30 June 2008

Image:1dbq.png

Template:STRUCTURE 1dbq

DNA-BINDING REGULATORY PROTEIN

Template:ABSTRACT PUBMED 7553867

About this Structure

1DBQ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Mechanism of corepressor-mediated specific DNA binding by the purine repressor., Schumacher MA, Choi KY, Lu F, Zalkin H, Brennan RG, Cell. 1995 Oct 6;83(1):147-55. PMID:7553867

Page seeded by OCA on Mon Jun 30 22:47:17 2008

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