1dbr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dbr.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1dbr.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dbr| PDB=1dbr | SCENE= }}
{{STRUCTURE_1dbr| PDB=1dbr | SCENE= }}
-
'''HYPOXANTHINE GUANINE XANTHINE'''
+
===HYPOXANTHINE GUANINE XANTHINE===
-
==Overview==
+
<!--
-
Crystal structures of substrate-free and XMP-soaked hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) of the opportunistic pathogen Toxoplasma gondii have been determined to 2.4 and 2.9 A resolution, respectively. HGXPRTase displays the conserved PRTase fold. In the structure of the enzyme bound to its product, a long flexible loop (residues 115-126) is located away from the active site. Comparison to the substrate-free structure reveals a striking relocation of the loop, which is poised to cover the catalytic pocket, thus providing a mechanism by which the HG(X)PRTases shield their oxocarbonium transition states from nucleophilic attack by the bulk solvent. The conserved Ser 117-Tyr 118 dipeptide within the loop is brought to the active site, completing the ensemble of catalytic residues.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8836106}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8836106 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8836106}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Purine salvage]]
[[Category: Purine salvage]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:40:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:47:19 2008''

Revision as of 19:47, 30 June 2008

Image:1dbr.png

Template:STRUCTURE 1dbr

HYPOXANTHINE GUANINE XANTHINE

Template:ABSTRACT PUBMED 8836106

About this Structure

1DBR is a Single protein structure of sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop., Schumacher MA, Carter D, Ross DS, Ullman B, Brennan RG, Nat Struct Biol. 1996 Oct;3(10):881-7. PMID:8836106

Page seeded by OCA on Mon Jun 30 22:47:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dbr"
Personal tools