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1dbr

From Proteopedia

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[[Image:1dbr.jpg|left|200px]]
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{{STRUCTURE_1dbr| PDB=1dbr | SCENE= }}
{{STRUCTURE_1dbr| PDB=1dbr | SCENE= }}
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'''HYPOXANTHINE GUANINE XANTHINE'''
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===HYPOXANTHINE GUANINE XANTHINE===
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==Overview==
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Crystal structures of substrate-free and XMP-soaked hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) of the opportunistic pathogen Toxoplasma gondii have been determined to 2.4 and 2.9 A resolution, respectively. HGXPRTase displays the conserved PRTase fold. In the structure of the enzyme bound to its product, a long flexible loop (residues 115-126) is located away from the active site. Comparison to the substrate-free structure reveals a striking relocation of the loop, which is poised to cover the catalytic pocket, thus providing a mechanism by which the HG(X)PRTases shield their oxocarbonium transition states from nucleophilic attack by the bulk solvent. The conserved Ser 117-Tyr 118 dipeptide within the loop is brought to the active site, completing the ensemble of catalytic residues.
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(as it appears on PubMed at http://www.pubmed.gov), where 8836106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8836106}}
==About this Structure==
==About this Structure==
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[[Category: Purine salvage]]
[[Category: Purine salvage]]
[[Category: Transferase]]
[[Category: Transferase]]
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Revision as of 19:47, 30 June 2008

Image:1dbr.png

Template:STRUCTURE 1dbr

HYPOXANTHINE GUANINE XANTHINE

Template:ABSTRACT PUBMED 8836106

About this Structure

1DBR is a Single protein structure of sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop., Schumacher MA, Carter D, Ross DS, Ullman B, Brennan RG, Nat Struct Biol. 1996 Oct;3(10):881-7. PMID:8836106

Page seeded by OCA on Mon Jun 30 22:47:19 2008

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