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1dd3

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{{STRUCTURE_1dd3| PDB=1dd3 | SCENE= }}
{{STRUCTURE_1dd3| PDB=1dd3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L12 FROM THERMOTOGA MARITIMA'''
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===CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L12 FROM THERMOTOGA MARITIMA===
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==Overview==
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Protein L12, the only multicopy component of the ribosome, is presumed to be involved in the binding of translation factors, stimulating factor-dependent GTP hydrolysis. Crystal structures of L12 from Thermotogamaritima have been solved in two space groups by the multiple anomalous dispersion method and refined at 2.4 and 2.0 A resolution. In both crystal forms, an asymmetric unit comprises two full-length L12 molecules and two N-terminal L12 fragments that are associated in a specific, hetero-tetrameric complex with one non-crystallographic 2-fold axis. The two full-length proteins form a tight, symmetric, parallel dimer, mainly through their N-terminal domains. Each monomer of this central dimer additionally associates in a different way with an N-terminal L12 fragment. Both dimerization modes are unlike models proposed previously and suggest that similar complexes may occur in vivo and in situ. The structures also display different L12 monomer conformations, in accord with the suggested dynamic role of the protein in the ribosomal translocation process. The structures have been submitted to the Protein Databank (http://www.rcsb.org/pdb) under accession numbers 1DD3 and 1DD4.
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(as it appears on PubMed at http://www.pubmed.gov), where 10637222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10637222}}
==About this Structure==
==About this Structure==
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[[Category: Helical hairpin]]
[[Category: Helical hairpin]]
[[Category: Hinge region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:42:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:50:49 2008''

Revision as of 19:50, 30 June 2008

Image:1dd3.png

Template:STRUCTURE 1dd3

CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L12 FROM THERMOTOGA MARITIMA

Template:ABSTRACT PUBMED 10637222

About this Structure

1DD3 is a Protein complex structure of sequences from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Flexibility, conformational diversity and two dimerization modes in complexes of ribosomal protein L12., Wahl MC, Bourenkov GP, Bartunik HD, Huber R, EMBO J. 2000 Jan 17;19(2):174-86. PMID:10637222

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