1ezj
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(New page: 200px<br /><applet load="1ezj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ezj, resolution 1.90Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 12:20, 20 November 2007
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CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS
Overview
The high resolution X-ray structure of the Sendai virus oligomerization, domain reveals a homotetrameric coiled coil structure with many details, that are different from classic coiled coils with canonical hydrophobic, heptad repeats. Alternatives to the classic knobs-into-holes packing lead, to differences in supercoil pitch and diameter that allow water molecules, inside the core. This open and more hydrophilic structure does not seem to, be destabilized by mutations that would be expected to disrupt classic, coiled coils.
About this Structure
1EZJ is a Single protein structure of sequence from Sendai virus with EMC and CA as ligands. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
Reference
Tetrameric coiled coil domain of Sendai virus phosphoprotein., Tarbouriech N, Curran J, Ruigrok RW, Burmeister WP, Nat Struct Biol. 2000 Sep;7(9):777-81. PMID:10966649
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