1ddw

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[[Image:1ddw.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ddw| PDB=1ddw | SCENE= }}
{{STRUCTURE_1ddw| PDB=1ddw | SCENE= }}
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'''HOMER EVH1 DOMAIN UNLIGANDED'''
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===HOMER EVH1 DOMAIN UNLIGANDED===
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==Overview==
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Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined the crystal structure of the Homer EVH1 domain complexed with a peptide from mGluR (TPPSPF). In contrast to other EVH1 domains, the bound mGluR ligand assumes an unusual conformation in which the side chains of the Ser-Pro tandem are oriented away from the Homer surface, and the Phe forms a unique contact. This unusual binding mode rationalizes conserved features of both Homer and Homer ligands that are not shared by other EVH1 domains. Site-directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer-ligand complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 10798399 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10798399}}
==About this Structure==
==About this Structure==
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[[Category: Xiao, B.]]
[[Category: Xiao, B.]]
[[Category: Pleckstrin homology domain fold]]
[[Category: Pleckstrin homology domain fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:44:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:45 2008''

Revision as of 19:52, 30 June 2008

Image:1ddw.png

Template:STRUCTURE 1ddw

HOMER EVH1 DOMAIN UNLIGANDED

Template:ABSTRACT PUBMED 10798399

About this Structure

1DDW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition., Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ, Neuron. 2000 Apr;26(1):143-54. PMID:10798399

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