1ddy

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{{STRUCTURE_1ddy| PDB=1ddy | SCENE= }}
{{STRUCTURE_1ddy| PDB=1ddy | SCENE= }}
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'''MOLECULAR RECOGNITION BY THE VITAMIN B12 RNA APTAMER'''
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===MOLECULAR RECOGNITION BY THE VITAMIN B12 RNA APTAMER===
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==Overview==
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Previous solution structures of ligand-binding RNA aptamers have shown that molecular recognition is achieved by the folding of an initially unstructured RNA around its cognate ligand, coupling the processes of RNA folding and binding. The 3 A crystal structure of the cyanocobalamin (vitamin B12) aptamer reported here suggests a different approach to molecular recognition in which elements of RNA secondary structure combine to create a solvent-accessible docking surface for a large, complex ligand. Central to this structure is a locally folding RNA triplex, stabilized by a novel three-stranded zipper. Perpendicular stacking of a duplex on this triplex creates a cleft that functions as the vitamin B12 binding site. Complementary packing of hydrophobic surfaces, direct hydrogen bonding and dipolar interactions between the ligand and the RNA appear to contribute to binding. The nature of the interactions that stabilize complex formation and the possible uncoupling of folding and binding for this RNA suggest a strong mechanistic similarity to typical protein-ligand complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 10625428 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10625428}}
==About this Structure==
==About this Structure==
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[[Category: Triplex]]
[[Category: Triplex]]
[[Category: Vitamin b12]]
[[Category: Vitamin b12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:44:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:55 2008''

Revision as of 19:52, 30 June 2008

Image:1ddy.png

Template:STRUCTURE 1ddy

MOLECULAR RECOGNITION BY THE VITAMIN B12 RNA APTAMER

Template:ABSTRACT PUBMED 10625428

About this Structure

Full crystallographic information is available from OCA.

Reference

The structural basis for molecular recognition by the vitamin B 12 RNA aptamer., Sussman D, Nix JC, Wilson C, Nat Struct Biol. 2000 Jan;7(1):53-7. PMID:10625428

Page seeded by OCA on Mon Jun 30 22:52:55 2008

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