1de4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1de4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1de4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1de4| PDB=1de4 | SCENE= }}
{{STRUCTURE_1de4| PDB=1de4 | SCENE= }}
-
'''HEMOCHROMATOSIS PROTEIN HFE COMPLEXED WITH TRANSFERRIN RECEPTOR'''
+
===HEMOCHROMATOSIS PROTEIN HFE COMPLEXED WITH TRANSFERRIN RECEPTOR===
-
==Overview==
+
<!--
-
HFE is related to major histocompatibility complex (MHC) class I proteins and is mutated in the iron-overload disease hereditary haemochromatosis. HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin. The 2.8 A crystal structure of a complex between the extracellular portions of HFE and TfR shows two HFE molecules which grasp each side of a twofold symmetric TfR dimer. On a cell membrane containing both proteins, HFE would 'lie down' parallel to the membrane, such that the HFE helices that delineate the counterpart of the MHC peptide-binding groove make extensive contacts with helices in the TfR dimerization domain. The structures of TfR alone and complexed with HFE differ in their domain arrangement and dimer interfaces, providing a mechanism for communicating binding events between TfR chains. The HFE-TfR complex suggests a binding site for transferrin on TfR and sheds light upon the function of HFE in regulating iron homeostasis.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10638746}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10638746 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10638746}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Mhc class i]]
[[Category: Mhc class i]]
[[Category: Transferrin receptor]]
[[Category: Transferrin receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:45:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:53:21 2008''

Revision as of 19:53, 30 June 2008

Image:1de4.png

Template:STRUCTURE 1de4

HEMOCHROMATOSIS PROTEIN HFE COMPLEXED WITH TRANSFERRIN RECEPTOR

Template:ABSTRACT PUBMED 10638746

About this Structure

1DE4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor., Bennett MJ, Lebron JA, Bjorkman PJ, Nature. 2000 Jan 6;403(6765):46-53. PMID:10638746

Page seeded by OCA on Mon Jun 30 22:53:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1de4"
Personal tools