1deg

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{{STRUCTURE_1deg| PDB=1deg | SCENE= }}
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'''THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE'''
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===THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE===
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==Overview==
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The crystal structure of a mutant calmodulin (CaM) lacking Glu-84 has been refined to R = 0.23 using data measured to 2.9-A resolution. In native CaM the central helix is fully extended, and the molecule is dumbbell shaped. In contrast, the deletion of Glu-84 causes a bend of 95 degrees in the linker region of the central helix at Ile-85. However, EF-hand domains 1 and 2 (lobe 1,2) do not touch lobe 3,4. The length, by alpha-carbon separation, of des-Glu84-CaM is 56 A; that of native CaM is 64 A. The shape of des-Glu84-CaM is similar to that of native CaM, as it is bound to the target peptide of myosin light-chain kinase. This result supports the proposal that the linker region of the central helix of CaM functions as a flexible tether.
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(as it appears on PubMed at http://www.pubmed.gov), where 8341712 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8341712}}
==About this Structure==
==About this Structure==
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[[Category: Sobottk, S E.]]
[[Category: Sobottk, S E.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:45:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:54:09 2008''

Revision as of 19:54, 30 June 2008

Image:1deg.png

Template:STRUCTURE 1deg

THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE

Template:ABSTRACT PUBMED 8341712

About this Structure

1DEG is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The linker of des-Glu84-calmodulin is bent., Raghunathan S, Chandross RJ, Cheng BP, Persechini A, Sobottka SE, Kretsinger RH, Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6869-73. PMID:8341712

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