1dem

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[[Image:1dem.gif|left|200px]]
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{{STRUCTURE_1dem| PDB=1dem | SCENE= }}
{{STRUCTURE_1dem| PDB=1dem | SCENE= }}
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'''PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS'''
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===PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS===
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==Overview==
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We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of &lt; 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.
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{{ABSTRACT_PUBMED_7544683}}
==About this Structure==
==About this Structure==
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1DEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEM OCA].
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1DEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEM OCA].
==Reference==
==Reference==
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[[Category: Foray, M F.]]
[[Category: Foray, M F.]]
[[Category: Lancelin, J M.]]
[[Category: Lancelin, J M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:46:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:54:34 2008''

Revision as of 19:54, 30 June 2008

Image:1dem.png

Template:STRUCTURE 1dem

PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS

Template:ABSTRACT PUBMED 7544683

About this Structure

1DEM is a Single protein structure of sequence from Dendroaspis polylepis polylepis. Full experimental information is available from OCA.

Reference

Proteinase inhibitor homologues as potassium channel blockers., Lancelin JM, Foray MF, Poncin M, Hollecker M, Marion D, Nat Struct Biol. 1994 Apr;1(4):246-50. PMID:7544683

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