1deq

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{{STRUCTURE_1deq| PDB=1deq | SCENE= }}
{{STRUCTURE_1deq| PDB=1deq | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION)'''
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===THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION)===
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==Overview==
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Here we report the crystal structure at approximately 4-A resolution of a selectively proteolyzed bovine fibrinogen. This key component in hemostasis is an elongated 340-kDa glycoprotein in the plasma that upon activation by thrombin self-assembles to form the fibrin clot. The crystals are unusual because they are made up of end-to-end bonded molecules that form flexible filaments. We have visualized the entire coiled-coil region of the molecule, which has a planar sigmoidal shape. The primary polymerization receptor pockets at the ends of the molecule face the same way throughout the end-to-end bonded filaments, and based on this conformation, we have developed an improved model of the two-stranded protofibril that is the basic building block in fibrin. Near the middle of the coiled-coil region, the plasmin-sensitive segment is a hinge about which the molecule adopts different conformations. This segment also includes the boundary between the three- and four-stranded portions of the coiled coil, indicating the location on the backbone that anchors the extended flexible Aalpha arm. We suggest that a flexible branch point in the molecule may help accommodate variability in the structure of the fibrin clot.
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(as it appears on PubMed at http://www.pubmed.gov), where 10618375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10618375}}
==About this Structure==
==About this Structure==
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[[Category: Volkmann, N.]]
[[Category: Volkmann, N.]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:46:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:54:50 2008''

Revision as of 19:54, 30 June 2008

Image:1deq.png

Template:STRUCTURE 1deq

THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION)

Template:ABSTRACT PUBMED 10618375

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of modified bovine fibrinogen., Brown JH, Volkmann N, Jun G, Henschen-Edman AH, Cohen C, Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):85-90. PMID:10618375

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