1dfj

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{{STRUCTURE_1dfj| PDB=1dfj | SCENE= }}
{{STRUCTURE_1dfj| PDB=1dfj | SCENE= }}
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'''RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A'''
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===RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A===
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==Overview==
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The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. We present here the crystal structure at 2.5 A resolution of the complex between ribonuclease A and ribonuclease inhibitor, a protein built entirely of leucine-rich repeats. The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel beta-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs. The structure can serve as a model for the interactions of other proteins containing leucine-rich repeats with their ligands.
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(as it appears on PubMed at http://www.pubmed.gov), where 7877692 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7877692}}
==About this Structure==
==About this Structure==
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[[Category: Leucine-rich repeat]]
[[Category: Leucine-rich repeat]]
[[Category: Ribonuclease]]
[[Category: Ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:47:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:00:06 2008''

Revision as of 20:00, 30 June 2008

Image:1dfj.png

Template:STRUCTURE 1dfj

RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A

Template:ABSTRACT PUBMED 7877692

About this Structure

1DFJ is a Protein complex structure of sequences from Bos taurus and Sus scrofa. Full crystallographic information is available from OCA.

Reference

A structural basis of the interactions between leucine-rich repeats and protein ligands., Kobe B, Deisenhofer J, Nature. 1995 Mar 9;374(6518):183-6. PMID:7877692

Page seeded by OCA on Mon Jun 30 23:00:06 2008

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