1dg2

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[[Image:1dg2.gif|left|200px]]
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{{STRUCTURE_1dg2| PDB=1dg2 | SCENE= }}
{{STRUCTURE_1dg2| PDB=1dg2 | SCENE= }}
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'''SOLUTION CONFORMATION OF A-CONOTOXIN AUIB'''
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===SOLUTION CONFORMATION OF A-CONOTOXIN AUIB===
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==Overview==
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The neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of alpha and beta subunits. alpha-Conotoxins are a homologous series of small peptides that antagonize these receptors. We present the three-dimensional solution structure of alpha-conotoxin AuIB, the first 15-residue alpha-conotoxin known to selectively block the alpha(3)beta(4) nicotinic acetylcholine receptor subtype. The pairwise backbone and heavy-atom root mean square deviation for an ensemble of 20 structures are 0.269 and 0.720 A, respectively. The overall fold of alpha-conotoxin AuIB closely resembles that of the alpha4/7 subfamily alpha-conotoxins. However, the absence of Tyr(15), normally present in other alpha4/7 members, results in tight bending of the backbone at the C terminus and effectively renders Asp(14) to assume the spatial location of Tyr(15) present in other neuronal alpha4/7 alpha-conotoxins. Structural comparison of alpha-conotoxin AuIB with the alpha(3)beta(2) subtype-specific alpha-conotoxin MII shows different electrostatic surface charge distributions, which may be important in differential receptor subtype recognition.
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{{ABSTRACT_PUBMED_10722709}}
==About this Structure==
==About this Structure==
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1DG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA].
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1DG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA].
==Reference==
==Reference==
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[[Category: A-helix]]
[[Category: A-helix]]
[[Category: Two disulfide bonds and c-term amidation]]
[[Category: Two disulfide bonds and c-term amidation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:48:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:01:36 2008''

Revision as of 20:01, 30 June 2008

Image:1dg2.png

Template:STRUCTURE 1dg2

SOLUTION CONFORMATION OF A-CONOTOXIN AUIB

Template:ABSTRACT PUBMED 10722709

About this Structure

1DG2 is a Single protein structure of sequence from Conus aulicus. Full experimental information is available from OCA.

Reference

Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist., Cho JH, Mok KH, Olivera BM, McIntosh JM, Park KH, Han KH, J Biol Chem. 2000 Mar 24;275(12):8680-5. PMID:10722709

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