1dgp

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{{STRUCTURE_1dgp| PDB=1dgp | SCENE= }}
{{STRUCTURE_1dgp| PDB=1dgp | SCENE= }}
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'''ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX'''
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===ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX===
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==Overview==
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The 2.5-A resolution crystal structure of recombinant aristolochene synthase from the blue cheese mold, Penicillium roqueforti, is the first of a fungal terpenoid cyclase. The structure of the enzyme reveals active site features that participate in the cyclization of the universal sesquiterpene cyclase substrate, farnesyl diphosphate, to form the bicyclic hydrocarbon aristolochene. Metal-triggered carbocation formation initiates the cyclization cascade, which proceeds through multiple complex intermediates to yield one exclusive structural and stereochemical isomer of aristolochene. Structural homology of this fungal cyclase with plant and bacterial terpenoid cyclases, despite minimal amino acid sequence identity, suggests divergence from a common, primordial ancestor in the evolution of terpene biosynthesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 10825154 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10825154}}
==About this Structure==
==About this Structure==
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[[Category: Isoprenoid biosynthesis]]
[[Category: Isoprenoid biosynthesis]]
[[Category: Sesquiterpene cyclase]]
[[Category: Sesquiterpene cyclase]]
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Revision as of 20:03, 30 June 2008

Image:1dgp.png

Template:STRUCTURE 1dgp

ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX

Template:ABSTRACT PUBMED 10825154

About this Structure

1DGP is a Single protein structure of sequence from Penicillium roqueforti. Full crystallographic information is available from OCA.

Reference

Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti., Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW, J Biol Chem. 2000 Aug 18;275(33):25533-9. PMID:10825154

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