1dgu

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[[Image:1dgu.jpg|left|200px]]
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{{STRUCTURE_1dgu| PDB=1dgu | SCENE= }}
{{STRUCTURE_1dgu| PDB=1dgu | SCENE= }}
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'''HOMOLOGY-BASED MODEL OF CALCIUM-SATURATED CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN)'''
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===HOMOLOGY-BASED MODEL OF CALCIUM-SATURATED CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN)===
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==Overview==
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Calcium- and integrin-binding protein (CIB) binds to the 20-residue alphaIIb cytoplasmic domain of platelet alphaIIbbeta3 integrin. Amino acid sequence similarities with calmodulin (CaM) and calcineurin B (CnB) allowed the construction of homology-based models of calcium-saturated CIB as well as apo-CIB. In addition, the solution structure of the alphaIIb cytoplasmic domain in 45% aqueous trifluoroethanol was solved by conventional two-dimensional NMR methods. The models indicate that the N-terminal domain of CIB possesses a number of positively charged residues in its binding site that could interact with the acidic carboxy-terminal LEEDDEEGE sequence of alphaIIb. The C-terminal domain of CIB seems well-suited to bind the sequence WKVGFFKR, which forms a well-structured alpha helix; this is analogous to calmodulin and calcineurin B, which also bind alpha helices. Similarities between the C-terminal domains of CIB and calmodulin suggest that binding of CIB to the cytoplasmic domain of alphaIIb may be affected by fluctuations in the intracellular calcium concentration.
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The line below this paragraph, {{ABSTRACT_PUBMED_10822252}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10822252 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10822252}}
==About this Structure==
==About this Structure==
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1DGU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGU OCA].
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1DGU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGU OCA].
==Reference==
==Reference==
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[[Category: Ef-hand]]
[[Category: Ef-hand]]
[[Category: Helical]]
[[Category: Helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:50:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:03:54 2008''

Revision as of 20:03, 30 June 2008

Image:1dgu.png

Template:STRUCTURE 1dgu

HOMOLOGY-BASED MODEL OF CALCIUM-SATURATED CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN)

Template:ABSTRACT PUBMED 10822252

About this Structure

1DGU is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies., Hwang PM, Vogel HJ, J Mol Recognit. 2000 Mar-Apr;13(2):83-92. PMID:10822252

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