1dhr

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[[Image:1dhr.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1dhr| PDB=1dhr | SCENE= }}
{{STRUCTURE_1dhr| PDB=1dhr | SCENE= }}
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'''CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE'''
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===CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE===
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==Overview==
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The structure of a binary complex of dihydropteridine reductase [DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase, EC 1.6.99.7] with its cofactor, NADH, has been solved and refined to a final R factor of 15.4% by using 2.3 A diffraction data. DHPR is an alpha/beta protein with a Rossmann-type dinucleotide fold for NADH binding. Insertion of an extra threonine residue in the human enzyme is associated with severe symptoms of a variant form of phenylketonuria and maps to a tightly linked sequence of secondary-structural elements near the dimer interface. Dimerization is mediated by a four-helix bundle motif (two helices from each protomer) having an unusual right-handed twist. DHPR is structurally and mechanistically distinct from dihydrofolate reductase, appearing to more closely resemble certain nicotinamide dinucleotide-requiring flavin-dependent enzymes, such as glutathione reductase.
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The line below this paragraph, {{ABSTRACT_PUBMED_1631094}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1631094 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1631094}}
==About this Structure==
==About this Structure==
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[[Category: Whiteley, J M.]]
[[Category: Whiteley, J M.]]
[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:51:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:04:54 2008''

Revision as of 20:04, 30 June 2008

Image:1dhr.png

Template:STRUCTURE 1dhr

CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE

Template:ABSTRACT PUBMED 1631094

About this Structure

1DHR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of rat liver dihydropteridine reductase., Varughese KI, Skinner MM, Whiteley JM, Matthews DA, Xuong NH, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6080-4. PMID:1631094

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