1dj0

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{{STRUCTURE_1dj0| PDB=1dj0 | SCENE= }}
{{STRUCTURE_1dj0| PDB=1dj0 | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION'''
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===THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION===
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==Overview==
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Pseudouridine synthases catalyze the isomerization of specific uridines to pseudouridine in a variety of RNAs, yet the basis for recognition of the RNA sites or how they catalyze this reaction is unknown. The crystal structure of pseudouridine synthase I from Escherichia coli, which, for example, modifies positions 38, 39 and/or 40 in tRNA, reveals a dimeric protein that contains two positively charged, RNA-binding clefts along the surface of the protein. Each cleft contains a highly conserved aspartic acid located at its center. The structural domains have a topological similarity to those of other RNA-binding proteins, though the mode of interaction with tRNA appears to be unique. The structure suggests that a dimeric enzyme is required for binding transfer RNA and subsequent pseudouridine formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 10625422 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10625422}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding motif]]
[[Category: Rna-binding motif]]
[[Category: Rna-modifying enzyme]]
[[Category: Rna-modifying enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:54:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:08:20 2008''

Revision as of 20:08, 30 June 2008

Image:1dj0.png

Template:STRUCTURE 1dj0

THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 10625422

About this Structure

1DJ0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I., Foster PG, Huang L, Santi DV, Stroud RM, Nat Struct Biol. 2000 Jan;7(1):23-7. PMID:10625422

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