1dk4

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{{STRUCTURE_1dk4| PDB=1dk4 | SCENE= }}
{{STRUCTURE_1dk4| PDB=1dk4 | SCENE= }}
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'''CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE'''
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===CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE===
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==Overview==
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In sequenced genomes, protein coding regions with unassigned function constitute between 10 and 50% of all open reading frames. Often key enzymes cannot be identified using sequence homology searches. For example, despite the fact that methanogens have an apparently functional gluconeogenesis pathway, standard tools have been unable to identify a fructose-1,6-bisphosphatase (FBPase) gene in the sequenced Methanoccocus jannaschii genome. Using a combination of functional and structural tools, we have shown that the protein product of the M. jannaschii gene MJ0109, which had been tentatively annotated as an inositol monophosphatase (IMPase), has both IMPase and FBPase activities. Moreover, several gene products annotated as IMPases from different thermophilic organisms also possess FBPase activity. Thus, we have found the FBPase that was 'missing' in thermophiles and shown that it also functions as an IMPase.
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{{ABSTRACT_PUBMED_11062561}}
==About this Structure==
==About this Structure==
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[[Category: Complexed with zn and pi]]
[[Category: Complexed with zn and pi]]
[[Category: Homodimer]]
[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:56:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:11:24 2008''

Revision as of 20:11, 30 June 2008

Image:1dk4.png

Template:STRUCTURE 1dk4

CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE

Template:ABSTRACT PUBMED 11062561

About this Structure

1DK4 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase., Stec B, Yang H, Johnson KA, Chen L, Roberts MF, Nat Struct Biol. 2000 Nov;7(11):1046-50. PMID:11062561

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