This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dkd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dkd.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1dkd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dkd| PDB=1dkd | SCENE= }}
{{STRUCTURE_1dkd| PDB=1dkd | SCENE= }}
-
'''CRYSTAL STRUCTURE OF A GROEL (APICAL DOMAIN) AND A DODECAMERIC PEPTIDE COMPLEX'''
+
===CRYSTAL STRUCTURE OF A GROEL (APICAL DOMAIN) AND A DODECAMERIC PEPTIDE COMPLEX===
-
==Overview==
+
<!--
-
The chaperonin GroEL is a double toriodal assembly that with its cochaperonin GroES facilitates protein folding with an ATP-dependent mechanism. Nonnative conformations of diverse protein substrates bind to the apical domains surrounding the opening of the double toroid's central cavity. Using phage display, we have selected peptides with high affinity for the isolated apical domain. We have determined the crystal structures of the complexes formed by the most strongly bound peptide with the isolated apical domain, and with GroEL. The peptide interacts with the groove between paired alpha helices in a manner similar to that of the GroES mobile loop. Our structural analysis, combined with other results, suggests that various modes of molecular plasticity are responsible for tight promiscuous binding of nonnative substrates and their release into the shielded cis assembly.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10619429}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10619429 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10619429}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Phage display]]
[[Category: Phage display]]
[[Category: Protein folding]]
[[Category: Protein folding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:57:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:12:03 2008''

Revision as of 20:12, 30 June 2008

Image:1dkd.png

Template:STRUCTURE 1dkd

CRYSTAL STRUCTURE OF A GROEL (APICAL DOMAIN) AND A DODECAMERIC PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 10619429

About this Structure

1DKD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity., Chen L, Sigler PB, Cell. 1999 Dec 23;99(7):757-68. PMID:10619429

Page seeded by OCA on Mon Jun 30 23:12:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dkd"
Personal tools