1dl0

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[[Image:1dl0.gif|left|200px]]
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{{Seed}}
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[[Image:1dl0.png|left|200px]]
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{{STRUCTURE_1dl0| PDB=1dl0 | SCENE= }}
{{STRUCTURE_1dl0| PDB=1dl0 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C'''
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===SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C===
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==Overview==
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We have isolated a family of insect-selective neurotoxins from the venom of the Australian funnel-web spider that appear to be good candidates for biopesticide engineering. These peptides, which we have named the Janus-faced atracotoxins (J-ACTXs), each contain 36 or 37 residues, with four disulfide bridges, and they show no homology to any sequences in the protein/DNA databases. The three-dimensional structure of one of these toxins reveals an extremely rare vicinal disulfide bridge that we demonstrate to be critical for insecticidal activity. We propose that J-ACTX comprises an ancestral protein fold that we refer to as the disulfide-directed beta-hairpin.
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The line below this paragraph, {{ABSTRACT_PUBMED_10881200}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10881200 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10881200}}
==About this Structure==
==About this Structure==
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1DL0 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL0 OCA].
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1DL0 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DL0 OCA].
==Reference==
==Reference==
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[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
[[Category: Vicinal disulfide]]
[[Category: Vicinal disulfide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:58:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:13:51 2008''

Revision as of 20:13, 30 June 2008

Image:1dl0.png

Template:STRUCTURE 1dl0

SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C

Template:ABSTRACT PUBMED 10881200

About this Structure

1DL0 is a Single protein structure. Full experimental information is available from OCA.

Reference

Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge., Wang X, Connor M, Smith R, Maciejewski MW, Howden ME, Nicholson GM, Christie MJ, King GF, Nat Struct Biol. 2000 Jun;7(6):505-13. PMID:10881200

Page seeded by OCA on Mon Jun 30 23:13:51 2008

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