1dlw

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[[Image:1dlw.gif|left|200px]]
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{{STRUCTURE_1dlw| PDB=1dlw | SCENE= }}
{{STRUCTURE_1dlw| PDB=1dlw | SCENE= }}
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'''X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.'''
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===X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.===
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==Overview==
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Small hemoproteins displaying amino acid sequences 20-40 residues shorter than (non-)vertebrate hemoglobins (Hbs) have recently been identified in several pathogenic and non-pathogenic unicellular organisms, and named 'truncated hemoglobins' (trHbs). They have been proposed to be involved not only in oxygen transport but also in other biological functions, such as protection against reactive nitrogen species, photosynthesis or to act as terminal oxidases. Crystal structures of trHbs from the ciliated protozoan Paramecium caudatum and the green unicellular alga Chlamydomonas eugametos show that the tertiary structure of both proteins is based on a 'two-over-two' alpha-helical sandwich, reflecting an unprecedented editing of the classical 'three-over-three' alpha-helical globin fold. Based on specific Gly-Gly motifs the tertiary structure accommodates the deletion of the N-terminal A-helix and replacement of the crucial heme-binding F-helix with an extended polypeptide loop. Additionally, concerted structural modifications allow burying of the heme group and define the distal site, which hosts a TyrB10, GlnE7 residue pair. A set of structural and amino acid sequence consensus rules for stabilizing the fold and the bound heme in the trHbs homology subfamily is deduced.
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The line below this paragraph, {{ABSTRACT_PUBMED_10835341}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10835341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10835341}}
==About this Structure==
==About this Structure==
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[[Category: Pesce, A.]]
[[Category: Pesce, A.]]
[[Category: Globin fold truncated hemoglobin non vertebrate hemoglobin]]
[[Category: Globin fold truncated hemoglobin non vertebrate hemoglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:00:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:16:11 2008''

Revision as of 20:16, 30 June 2008

Image:1dlw.png

Template:STRUCTURE 1dlw

X-RAY CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM P.CAUDATUM.

Template:ABSTRACT PUBMED 10835341

About this Structure

1DLW is a Single protein structure of sequence from Paramecium caudatum. Full crystallographic information is available from OCA.

Reference

A novel two-over-two alpha-helical sandwich fold is characteristic of the truncated hemoglobin family., Pesce A, Couture M, Dewilde S, Guertin M, Yamauchi K, Ascenzi P, Moens L, Bolognesi M, EMBO J. 2000 Jun 1;19(11):2424-34. PMID:10835341

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