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1dm4

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[[Image:1dm4.gif|left|200px]]
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{{STRUCTURE_1dm4| PDB=1dm4 | SCENE= }}
{{STRUCTURE_1dm4| PDB=1dm4 | SCENE= }}
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'''SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)'''
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===SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)===
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==Overview==
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The Ser195Ala mutant of human alpha-thrombin was complexed with fibrinopeptide A(7-22) (FPA) in an effort to describe the (P1'-P6') post-cleavage binding subsites of the fibrinogen-recognition exosite and define more clearly the nature of the Michaelis complex and the scissile peptide bond bound at the catalytic site. The thrombin mutant, however, has residual catalytic activity and proteolysis occurred at the Arg16-Gly17 bond. Thus, the structure of the thrombin complex determined was that of FPA(7-16) bound at the active site, which is very similar to the ternary FPA(7-16)cmk-human thrombin-hirugen complex (r.m.s.d. approximately 0.4 A; Stubbs et al. , 1992). It is further shown by subsidiary experiments that the cleavage is the result of residual catalytic activity of the altered catalytic machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 10739913 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10739913}}
==About this Structure==
==About this Structure==
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[[Category: Mutant thrombin]]
[[Category: Mutant thrombin]]
[[Category: Residual catalytic activity]]
[[Category: Residual catalytic activity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:00:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:16:47 2008''

Revision as of 20:16, 30 June 2008

Image:1dm4.png

Template:STRUCTURE 1dm4

SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)

Template:ABSTRACT PUBMED 10739913

About this Structure

1DM4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity., Krishnan R, Sadler JE, Tulinsky A, Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):406-10. PMID:10739913

Page seeded by OCA on Mon Jun 30 23:16:47 2008

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