1dmz

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[[Image:1dmz.gif|left|200px]]
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{{STRUCTURE_1dmz| PDB=1dmz | SCENE= }}
{{STRUCTURE_1dmz| PDB=1dmz | SCENE= }}
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'''A REFINED NMR STRUCTURE OF A NEW PHOPHOPEPTIDE-BINDING DOMAIN CONTAINING THE FHA2 OF RAD53'''
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===A REFINED NMR STRUCTURE OF A NEW PHOPHOPEPTIDE-BINDING DOMAIN CONTAINING THE FHA2 OF RAD53===
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==Overview==
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The forkhead-associated (FHA) domain is a 55-75 amino acid residue module found in &gt;20 proteins from yeast to human. It has been suggested to participate in signal transduction pathways, perhaps via protein-protein interactions involving recognition of phosphopeptides. Neither the structure nor the ligand of FHA is known. Yeast Rad53, a checkpoint protein involved in DNA damage response, contains two FHA domains, FHA1 (residues 66-116) and FHA2 (residues 601-664), the second of which recognizes phosphorylated Rad9. We herein report the solution structure of an "FHA2-containing domain" of Rad53 (residues 573-730). The structure consists of a beta-sandwich containing two antiparallel beta-sheets and a short, C-terminal alpha-helix. Binding experiments suggested that the FHA2-containing domain specifically recognizes pTyr and a pTyr-containing peptide from Rad9, and that the binding site involves residues highly conserved across FHA domains. The results, along with other recent reports, suggest that FHA domains could have pTyr and pSer/Thr dual specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_10588905}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10588905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10588905}}
==About this Structure==
==About this Structure==
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1DMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DMZ OCA].
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1DMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DMZ OCA].
==Reference==
==Reference==
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[[Category: Beta-sandwich]]
[[Category: Beta-sandwich]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:02:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:19:10 2008''

Revision as of 20:19, 30 June 2008

Image:1dmz.png

Template:STRUCTURE 1dmz

A REFINED NMR STRUCTURE OF A NEW PHOPHOPEPTIDE-BINDING DOMAIN CONTAINING THE FHA2 OF RAD53

Template:ABSTRACT PUBMED 10588905

About this Structure

1DMZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53., Liao H, Byeon IJ, Tsai MD, J Mol Biol. 1999 Dec 10;294(4):1041-9. PMID:10588905

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